Most noradrenergic of the SNRIs, good for fatigue, with side effect profile similar to bupropion. Isomer of milnacipran (used in…

For mood disorders with meth/cocaine abuse [1], age-related cognitive decline [1], and post-stroke depression [2]…

[PEA] For mania [3], and augments antidepressants in unipolar [3], autism, neg symptom schizophrenia, migraines and chronic pain….

For depression [3] and negative symptoms of schizophrenia…

[ALC] Depression, especially recurrent/TRD, history of child-trauma, or with medical illness or elderly [2]. Alcohol (mood/memory/cravings) [2]…

Very effective and well tolerated for depression regardless of season (also for bipolar, PTSD, bulimia, shift work)…

Augments SSRIs in women only [3]. Improves memory, especially in older adults [2]. Long-COVID [3]….

For depression, improves liver health, osteoarthritis, but l-methylfolate has a similar mechanism and better evidence….

Well-studied in depression [1], sleep, cognition. Small trials in ADHD [3], OCD [3], weight loss [3], sexual dysfunction [3]….

For bipolar/unipolar depression [2], ADHD [3], anxiety [2], cognition [2], autism [2], weight loss [1], dyslipidemia, long COVID [1]….

Extract of green tea. Depression [3], sleep [2], schizophrenia (neg/anx) [2], OCD [3], cognition [3]….

[Pamelor] First-line tricyclic, low sedation/anticholinergic/hypotension risk. More noradrenergic….

[Elavil] Third-line tricyclic, mix of serotonin/noripineprhine, more anticholinergic side effects. Useful for pain and IBS….

[Zoloft] Good choice overall, best SSRI for heart disease, no CYP drug interactions below 150mg….

[Wellbutrin] First-line for depression (lacks weight-gain, sexual, cognitive, fatigue SEs; lack of WD). Safest antidepressant in bipolar. Treats nicotine but…

Deepens sleep quality in low doses, but under-utlilized as an antidepressant, where it can be very effective and tolerable if…

Herb that helps with mild depression and stress management….

[Fish oil] For bipolar/unipolar depression [2], ADHD, [3], borderline pd [2], irritability, autism, [2], prevention of psychosis [1], dyslipidemia….

[Cymbalta] Approved for child anxiety. Risk of urine retention (but treats urine incont). Liver risk….

[Effexor] Not ideal among the SNRIs (hypertension, WD risks, weight gain), but very effective for some and treats hot flashes…

[Prozac] Best SSRI for children, weight loss, low WD risk, and bulimia….

[Luvox] Only approved in OCD….

[Mirapex] Dopamine agonist with powerful benefits in unipolar and bipolar depression, also restless leg syndrome….

Multivitamin with methylfolate, omega-3, and more. Large effect in depression [1]…

[$ Exxua] Similar to buspirone but not as useful (costly, requires EKG testing, failed in most depression trials)…

[$ EMSAM] Skin patch MAOI, good to start with (low dose = no food interactions) but not as potent as…

[Lexapro] First-line SSRI (no drug interactions, good efficacy in depression/anxiety)….

[$ Trintellix] Improves cognition. First-line for depression (lacks weight gain, sexual, fatigue SEs; lack of WS). Well studied in elderly….