Solriamfetol
Varenicline
Nicotine Replacement
Thyroid T4
Thyroid T3
Tranylcypromine
Phenelzine
Iscarboxazid
Selegiline
Semaglutide
Liraglutide
Ropinorole
Esketamine
Maca root
Inositol
Probiotics
Citicoline
Aniracetam
Vitamin D3
Sensoril
Rhodiola rosea
Zinc
Coenzyme q10
SAMe
L-methylfolate
Creatine
Pramiracetam
Piracetam
Enlyte
Template
Melatonin
Cocoavia
Sarcosine
l-Theanine
Ginkgo
Micronutrients
Vitamin B6
Acetyl-l-carnitine
Saffron
Pycnoginol
l-Carnosine
Curcumin
Chamomile
Phosphatidylserine
Palmitoylethanolamide
Lavender
Omega 3 (Fish oil)
Vitamin B-complex
Calcium
Xanomeline-trospium
Depression
Vitamin B-complex
For depression [3] and negative symptoms of schizophrenia…
Acetyl-l-carnitine
[ALC] Depression, especially recurrent/TRD, history of child-trauma, or with medical illness or elderly [2]. Alcohol (mood/memory/cravings) [2]…
Lightbox
Very effective and well tolerated for depression regardless of season (also for bipolar, PTSD, bulimia, shift work)…
Creatine
Augments SSRIs in women only [3]. Improves memory, especially in older adults [2]. Long-COVID [3]….
SAMe
For depression, improves liver health, osteoarthritis, but l-methylfolate has a similar mechanism and better evidence….
Saffron
Well-studied in depression [1], sleep, cognition. Small trials in ADHD [3], OCD [3], weight loss [3], sexual dysfunction [3]….
Probiotics
For bipolar/unipolar depression [2], ADHD [3], anxiety [2], cognition [2], autism [2], weight loss [1], dyslipidemia, long COVID [1]….
l-Theanine
Extract of green tea. Depression [3], sleep [2], schizophrenia (neg/anx) [2], OCD [3], cognition [3]….
Nortriptyline
[Pamelor] First-line tricyclic, low sedation/anticholinergic/hypotension risk. More noradrenergic….
Amitriptyline
[Elavil] Third-line tricyclic, mix of serotonin/noripineprhine, more anticholinergic side effects. Useful for pain and IBS….
Sertraline
[Zoloft] Good choice overall, best SSRI for heart disease, no CYP drug interactions below 150mg….
Bupropion
[Wellbutrin] First-line for depression (lacks weight-gain, sexual, cognitive, fatigue SEs; lack of WD). Safest antidepressant in bipolar. Treats nicotine but…
Trazodone
Deepens sleep quality in low doses, but under-utlilized as an antidepressant, where it can be very effective and tolerable if…
Rhodiola rosea
Herb that helps with mild depression and stress management….
Omega 3 (Fish oil)
[Fish oil] For bipolar/unipolar depression [2], ADHD, [3], borderline pd [2], irritability, autism, [2], prevention of psychosis [1], dyslipidemia….
Duloxetine
[Cymbalta] Approved for child anxiety. Risk of urine retention (but treats urine incont). Liver risk….
Venlafaxine
[Effexor] Not ideal among the SNRIs (hypertension, WD risks, weight gain), but very effective for some and treats hot flashes…
Palmitoylethanolamide
[PEA] For mania [3], and augments antidepressants in unipolar [3], autism, neg symptom schizophrenia, migraines and chronic pain….
Fluoxetine
[Prozac] Best SSRI for children, weight loss, low WD risk, and bulimia….
Fluvoxamine
[Luvox] Only approved in OCD….
Levomilnacipran
[$ Fetzima] Most noradrenergic of the SNRIs, good for fatigue, with side effect profile similar to bupropion. Isomer of milnacipran (used…
Pramipexole
[Mirapex] Dopamine agonist with powerful benefits in unipolar and bipolar depression, also restless leg syndrome….
Enlyte
Multivitamin with methylfolate, omega-3, and more. Large effect in depression [1]…
Gepirone
[$ Exxua] Similar to buspirone but not as useful (costly, requires EKG testing, failed in most depression trials)…
Selegiline
[$ EMSAM] Skin patch MAOI, good to start with (low dose = no food interactions) but not as potent as…
Escitalopram
[Lexapro] First-line SSRI (no drug interactions, good efficacy in depression/anxiety)….
Vortioxetine
[$ Trintellix] Improves cognition. First-line for depression (lacks weight gain, sexual, fatigue SEs; lack of WS). Well studied in elderly….
Buspirone-melatonin combo
Low doses of both treated depression in one trial….
