Clonidine
Prazosin
Doxazosin
Verapamil
Nimodipine
Isradipine
Pindolol
Hydroxyzine
Buspirone-melatonin combo
Vortioxetine
Vilazodone
Bupropion
Lamotrigine
Carbamazepine
Zonisamide
Valproate
Pregabalin
Gabapentin
Topiramate
Minocycline
Cycloserine
Amantadine
Valbenazine
Deutetrabenazine
Vitamin E
Levetiracetam
Hydrocortisone
Sertraline
Paroxetine
Fluvoxamine
Escitalopram
Citalopram
Vardenafil
Tadalafil
Sildenafil
Bremelanotide
Zestra
Arginmax
Flibanserin
Zuranolone
Naloxone
Lofexidine
Buprenorphine-naloxone
Naproxyn
Ondansetron
Granisetron
Gepirone
Nefazodone
Mirtazapine
Trazodone
Depression
Vitamin B-complex
For depression [3] and negative symptoms of schizophrenia…
Acetyl-l-carnitine
[ALC] Depression, especially recurrent/TRD, history of child-trauma, or with medical illness or elderly [2]. Alcohol (mood/memory/cravings) [2]…
Lightbox
Very effective and well tolerated for depression regardless of season (also for bipolar, PTSD, bulimia, shift work)…
Creatine
Augments SSRIs in women only [3]. Improves memory, especially in older adults [2]. Long-COVID [3]….
SAMe
For depression, improves liver health, osteoarthritis, but l-methylfolate has a similar mechanism and better evidence….
Saffron
Well-studied in depression [1], sleep, cognition. Small trials in ADHD [3], OCD [3], weight loss [3], sexual dysfunction [3]….
Probiotics
For bipolar/unipolar depression [2], ADHD [3], anxiety [2], cognition [2], autism [2], weight loss [1], dyslipidemia, long COVID [1]….
l-Theanine
Extract of green tea. Depression [3], sleep [2], schizophrenia (neg/anx) [2], OCD [3], cognition [3]….
Nortriptyline
[Pamelor] First-line tricyclic, low sedation/anticholinergic/hypotension risk. More noradrenergic….
Amitriptyline
[Elavil] Third-line tricyclic, mix of serotonin/noripineprhine, more anticholinergic side effects. Useful for pain and IBS….
Sertraline
[Zoloft] Good choice overall, best SSRI for heart disease, no CYP drug interactions below 150mg….
Bupropion
[Wellbutrin] First-line for depression (lacks weight-gain, sexual, cognitive, fatigue SEs; lack of WD). Safest antidepressant in bipolar. Treats nicotine but…
Trazodone
Deepens sleep quality in low doses, but under-utlilized as an antidepressant, where it can be very effective and tolerable if…
Rhodiola rosea
Herb that helps with mild depression and stress management….
Omega 3 (Fish oil)
[Fish oil] For bipolar/unipolar depression [2], ADHD, [3], borderline pd [2], irritability, autism, [2], prevention of psychosis [1], dyslipidemia….
Duloxetine
[Cymbalta] Approved for child anxiety. Risk of urine retention (but treats urine incont). Liver risk….
Venlafaxine
[Effexor] Not ideal among the SNRIs (hypertension, WD risks, weight gain), but very effective for some and treats hot flashes…
Palmitoylethanolamide
[PEA] For mania [3], and augments antidepressants in unipolar [3], autism, neg symptom schizophrenia, migraines and chronic pain….
Fluoxetine
[Prozac] Best SSRI for children, weight loss, low WD risk, and bulimia….
Fluvoxamine
[Luvox] Only approved in OCD….
Levomilnacipran
[$ Fetzima] Most noradrenergic of the SNRIs, good for fatigue, with side effect profile similar to bupropion. Isomer of milnacipran (used…
Pramipexole
[Mirapex] Dopamine agonist with powerful benefits in unipolar and bipolar depression, also restless leg syndrome….
Enlyte
Multivitamin with methylfolate, omega-3, and more. Large effect in depression [1]…
Gepirone
[$ Exxua] Similar to buspirone but not as useful (costly, requires EKG testing, failed in most depression trials)…
Selegiline
[$ EMSAM] Skin patch MAOI, good to start with (low dose = no food interactions) but not as potent as…
Escitalopram
[Lexapro] First-line SSRI (no drug interactions, good efficacy in depression/anxiety)….
Vortioxetine
[$ Trintellix] Improves cognition. First-line for depression (lacks weight gain, sexual, fatigue SEs; lack of WS). Well studied in elderly….
Buspirone-melatonin combo
Low doses of both treated depression in one trial….
