Daridorexant
[$ Quviviq] Orexin antagonist, improves next-day cognition, low abuse potential, low fall risk. Ideal for elderly.
Tolerable
Ramelteon
[Rozerem] Safe hypnotic that may improve depression in bipolar disorder. Think of it as a potent melatonin.
Eszopiclone
[Lunesta]Among the z-hypnotics, has the most benzo-like properties, and can augment antidepressants (short term) in depression and GAD.
Buspirone
Treats anxiety (GAD). Augments in depression but only if anxious. Also improves sexual dysf, bruxism, irritability, PMDD, possibly ADHD.
Celecoxib
[Celebrex] NSAID for treatment-resistant unipolar and bipolar depression, works better if inflammation. Well-tolerated short term, but long-term risks.