Zuranolone
[$ Zurzuvae] First-line for post-partum depression, but not for regular depression or post-partum psychosis. Safe in bipolar. 2-week course; benzo-like properties.
Tolerable
Naloxone
Opioid blocker, good to prescribe (for OTC) to family if patient at risk of OD (even if you aren’t prescribing the opioid).
Buprenorphine-naloxone
[Suboxone] First line for opioid use disorders
Buprenorphine-naloxone Read More »
Gepirone
[$ Exxua] Similar to buspirone but not as useful (costly, requires EKG testing, failed in most depression trials)
Trazadone
[Desyrel] Deepens sleep quality in low doses, but under-utlilized as an antidepressant, where it can be very effective and tolerable if dosed at night.
Suvorexant
[$ Belsomra] Orexin antagonist, improves next-day congnition, low abuse potential, low fall risk. Ideal for elderly. However, daridorexant and lemborexant more effective.
Lemborexant
[$ Dayvigo] Orexin antagonist, improves next-day cognition, low abuse potential, low fall risk. Ideal for elderly.