Chamomile
Improves sleep quality [3] and postmenopausal sexual function [3], but barely effective in anxiety [4].
Sedating
Lavender
[Silexan] First-line for generalized anxiety, Prescription and approved outside US. Well-tolerated, safe in bipolar.
Xanomeline-trospium
[$ Cobenfy] First-line antipsychotic for schizophrenia (lacks long-term risks, though GI issues a problem at start). Not effective in other disorders.
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Guanfacine
[Intuniv] Approved for ADHD [2], less sedating than clonidine but not as useful in comorbidities. Tics.
Clonidine
[Kapvay] Approved for ADHD, but also helps mania, nicotine/opioid, anxiety, irritability, self-harm, autism, negative symptoms schizophrenia, tics
Pindolol
Speeds up antidepressants [3] when started with an SSRI (doesn’t augment later after starting SSRI). Augments in OCD/panic [3]
Hydroxyzine
[Vistaril] A better tolerated prescription version of diphenhydramine (Benadryl) for anxiety and insomnia.
Buspirone-melatonin combo
Low doses of both treated depression in one trial.
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