Clonidine
[Kapvay] Approved for ADHD, but also helps mania, nicotine/opioid, anxiety, irritability, self-harm, autism, negative symptoms schizophrenia, tics
Medication
Nimodipine
[CA CHANNEL BLOCKER] for mania [3], rapid cycling bipolar, and tremor, (may help bp-anxiety).
Pindolol
Speeds up antidepressants [3] when started with an SSRI (doesn’t augment later after starting SSRI). Augments in OCD/panic [3]
Hydroxyzine
[Vistaril] A better tolerated prescription version of diphenhydramine (Benadryl) for anxiety and insomnia.
Buspirone-melatonin combo
Low doses of both treated depression in one trial.
Buspirone-melatonin combo Read More »
Vortioxetine
[$ Trintellix] Improves cognition. First-line for depression (lacks weight gain, sexual, fatigue SEs; lack of WS). Well studied in elderly.
Vilazodone
[Viibryd] Only benefit is lack of sexual side effects. Otherwise, not evidence in anxiety and not a stand-out antidepressant.