Acetyl-l-carnitine
[ALC] Depression, especially recurrent/TRD, history of child-trauma, or with medical illness or elderly [2]. Alcohol (mood/memory/cravings) [2]
Acetyl-l-carnitine Read More »
Substance Use Disorders
Saffron
Well-studied in depression [1], sleep, cognition. Small trials in ADHD [3], OCD [3], weight loss [3], sexual dysfunction [3].
Clonidine
[Kapvay] Approved for ADHD, but also helps mania, nicotine/opioid, anxiety, irritability, self-harm, autism, negative symptoms schizophrenia, tics
Bupropion
[Wellbutrin] First-line for depression (lacks weight-gain, sexual, cognitive, fatigue SEs; lack of WD). Safest antidepressant in bipolar. Treats nicotine but not as well as varenicline. Treats ADHD a little; RLS.
Pregabalin
[Lyrica] Approved outside US for generalized and social anxiety disorders [1]. Benzo WD, OCD [3], fibromylagia [1].
Gabapentin
[Neurontin] For social anxiety, stabilizing sleep in alcoholics, RLS, akathisia, non-specific anxiety. Better tolerated than pregabalin but less effective.
Topiramate
[Topamax] PTSD [2], alcohol [2], bulimia [1], borderline/aggression [3], weight [2], OCD [3], meth [1], cocaine [2], gambling [2], schizophrenia aug [1] migraines
Naloxone
Opioid blocker, good to prescribe (for OTC) to family if patient at risk of OD (even if you aren’t prescribing the opioid).