Benzodiazepines
Lorazepam is best overall. Oxazepam safest. Clonazepam, alprazolam approved in panic. Alprazolam short-term helps depression. Akathisia, alcohol WD.
Hypnotics
Dawn-Simulator
Improves morning fatigue and depression, particularly in winter. Can pair with lightbox for depression. Ideal for shift workers and night owls.
Melatonin
Hypnotic with particular benefits in elderly and children with developmental disorders [1], and antipsychotic weight loss [1].
l-Theanine
Extract of green tea. Depression [3], sleep [2], schizophrenia (neg/anx) [2], OCD [3], cognition [3].
Saffron
Well-studied in depression [1], sleep, cognition. Small trials in ADHD [3], OCD [3], weight loss [3], sexual dysfunction [3].
Chamomile
Improves sleep quality [3] and postmenopausal sexual function [3], but barely effective in anxiety [4].
Lavender
[Silexan] First-line for generalized anxiety, Prescription and approved outside US. Well-tolerated, safe in bipolar.
Clonidine
[Kapvay] Approved for ADHD, but also helps mania, nicotine/opioid, anxiety, irritability, self-harm, autism, negative symptoms schizophrenia, tics
Hydroxyzine
[Vistaril] A better tolerated prescription version of diphenhydramine (Benadryl) for anxiety and insomnia.