Lightbox
Very effective and well tolerated for depression regardless of season (also for bipolar, PTSD, bulimia, shift work)
Fibromyalgia
Levomilnacipran
[$ Fetzima] Most noradrenergic of the SNRIs, good for fatigue, with side effect profile similar to
bupropion. Isomer of milnacipran (used in fibromylagia).
Duloxetine
[Cymbalta] Approved for child anxiety. Risk of urine retention (but treats urine incont). Liver
risk.
Coenzyme q10
For bipolar and unipolar depression [2], ADHD [3], autism [2], neurodevelopmental disorders [2], and energy in elderly.
SAMe
For depression, improves liver health, osteoarthritis, but l-methylfolate has a similar mechanism and better evidence.
Creatine
Augments SSRIs in women only [3]. Improves memory, especially in older adults [2]. Long-COVID [3].
Pregabalin
[Lyrica] Approved outside US for generalized and social anxiety disorders [1]. Benzo WD, OCD [3], fibromylagia [1].
Gabapentin
[Neurontin] For social anxiety, stabilizing sleep in alcoholics, RLS, akathisia, non-specific anxiety. Better tolerated than pregabalin but less effective.