Bupropion
[Wellbutrin] First-line for depression (lacks weight-gain, sexual, cognitive, fatigue SEs; lack of WD). Safest antidepressant in bipolar. Treats nicotine but not as well as varenicline. Treats ADHD a little; RLS.
Weight Loss
Lamotrigine
[Lamictal] Best tolerated mood stabilizer, treats and prevents bp-depression; does not treat mania so avoid as monotherapy in bipolar I.
Topiramate
[Topamax] PTSD [2], alcohol [2], bulimia [1], borderline/aggression [3], weight [2], OCD [3], meth [1], cocaine [2], gambling [2], schizophrenia aug [1] migraines
Amantadine
Similar to ketamine. Treats TD [2] and irritability in TBI [1]. Last-line secret-weapon for bipolar/unipolar depression, OCD, cognition, DMDD, autism, weight-loss, fatigue.
Methylphenidate
First-line stimulant (more neuroprotective and safer for mental health than amphetamine). May help apathy in old age but not for depression.
Amphetamine
Amphetamine Stimulant (dopamine-norepinephrine reuptake inhibitor and releaser; serotonin reuptake inhibition) Features Dosing Dextroamphetamine Dextro is the more potent of the
Modafinils
[Provigil, Nuvigil] Wakefulness-promoting agents FDA approved for fatigue associated with sleep apnea or shift work. Also treats bipolar depression (2), unipolar depression (3), ADHD (3), and cocaine use disorder.
Atomoxetine
Good for ADHD with anxiety, but least effective among FDA options for ADHD. Avoid in bipolar.
Naltrexone
[Vivitrol] Opioid blocker treats alcohol and opioid use disorders (and, in combination with bupropion, meth). May help gambling addiciton and antipsychotic weight gain. Inj or oral.