Dark-Therapy
Very effective for mania, prevents bipolar, deepens sleep. Mild weight loss.
Weight Loss
Metformin
First-line for antipsychotic weight gain, works best when started early (also prevents DM, dyslipidemia, prolactinemia)
Tirzepatide
[$ Mounjaro, Zepbound] Most effective of the GLPs for weight loss (use if BMI >30 or > 27 with complications of obesity).
Thyroid T4
[Synthroid] Use for hypothyroidism on lithium. For augmentation in depression, T3 is preferred.
Thyroid T3
[Cytomel] For treatment-resistant bipolar/unipolar depression, well-tolerated and may actually improve manic or anxious symptoms
Semaglutide
[$ Ozempic, Wegovy] Medium effective of the GLPs for weight loss (use if BMI >30 or > 27 with complications of obesity).
Melatonin
Hypnotic with particular benefits in elderly and children with developmental disorders [1], and antipsychotic weight loss [1].
Saffron
Well-studied in depression [1], sleep, cognition. Small trials in ADHD [3], OCD [3], weight loss [3], sexual dysfunction [3].
Omega 3 (Fish oil)
[Fish oil] For bipolar/unipolar depression [2], ADHD, [3], borderline pd [2], irritability, autism, [2], prevention of psychosis [1], dyslipidemia.
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