Methylphenidate
First-line stimulant (more neuroprotective and safer for mental health than amphetamine). May help apathy in old age but not for depression.
Weight-Free
Amphetamine
Amphetamine Stimulant (dopamine-norepinephrine reuptake inhibitor and releaser; serotonin reuptake inhibition) Features Dosing Dextroamphetamine Dextro is the more potent of the
Modafinils
[Provigil, Nuvigil] Wakefulness-promoting agents FDA approved for fatigue associated with sleep apnea or shift work. Also treats bipolar depression (2), unipolar depression (3), ADHD (3), and cocaine use disorder.
Viloxazine
Viloxazine ($ Qelbree) Antidepressant structure (norepinephrine reuptake inhibitor) Avoid in bipolar Features Dosing Start 100-200mg daily, raise every week. Max
Atomoxetine
Atomoxetine (Straterra) Antidepressant structure (norepinephrine reuptake inhibitor) Features Dosing 40-100mg/d. Start 40mg 1 qd x7days then 2 qd (take after
Methylphenidate
Methylphenidate Stimulant (dopamine-norepinephrine reuptake inhibitor and releaser; serotonin reuptake inhibition) Features Dosing Dexmethylphenidate is the active isomer (levo is inactive).
Naltrexone
[Vivitrol] Opioid blocker treats alcohol and opioid use disorders (and, in combination with bupropion, meth). May help gambling addiciton and antipsychotic weight gain. Inj or oral.
Pramipexole
Dopamine agonist with powerful benefits in unipolar and bipolar depression, also restless leg syndrome.