Naloxone
Opioid blocker, good to prescribe (for OTC) to family if patient at risk of OD (even if you aren’t prescribing the opioid).
Tolerable
Buprenorphine-naloxone
[Suboxone] First line for opioid use disorders
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Ondansetron
[Zofran] First-line for OCD (very effective, well tolerated). May help binge drinking, bulimia.
Gepirone
[$ Exxua] Similar to buspirone but not as useful (costly, requires EKG testing, failed in most depression trials)
Trazodone
Deepens sleep quality in low doses, but under-utlilized as an antidepressant, where it can be very effective and tolerable if dosed at night.
Suvorexant
[$ Belsomra] Orexin antagonist, improves next-day cognition, low abuse potential, low fall risk. Ideal for elderly. However, daridorexant and lemborexant more effective.
Lemborexant
[$ Dayvigo] Orexin antagonist, improves next-day cognition, low abuse potential, low fall risk. Ideal for elderly.
Daridorexant
[$ Quviviq] Orexin antagonist, improves next-day cognition, low abuse potential, low fall risk. Ideal for elderly.