Allopurinol
A well tolerated option for mania, but third-line due to few trials.
Non-sedating
Buspirone
Treats anxiety (GAD). Augments in depression but only if anxious. Also improves sexual dysf, bruxism, irritability, PMDD, possibly ADHD.
Lithium
Best long-term outcomes in bipolar (I or II) and recurrent depression. Prevents suicide. Treats mania, bp-depression and augments antidepressants.
Celecoxib
[Celebrex] NSAID for treatment-resistant unipolar and bipolar depression, works better if inflammation. Well-tolerated short term, but long-term risks.
Acamprosate
[Campral] Well tolerated but low efficacy for alcohol use disorder. May make WD symptoms less aversive.