Micronutrients
[Empowerplus] Although advertised in bipolar disorder, these branded multivitamins only have evidence in lability in ADHD. Prefer Enlyte for mood.
Natural
Vitamin B6
Improves mood, PMDD, and treats side effects of lithium/antipsychotics (tremor, hyperprolactin, akathisia, EPS, TD)
Acetyl-l-carnitine
[ALC] Depression, especially recurrent/TRD, history of child-trauma, or with medical illness or elderly [2]. Alcohol (mood/memory/cravings) [2]
Acetyl-l-carnitine Read More »
Saffron
Well-studied in depression [1], sleep, cognition. Small trials in ADHD [3], OCD [3], weight loss [3], sexual dysfunction [3].
l-Carnosine
For depression [3], ADHD [3], OCD [3], cognition [3], schizophrenia negative symptoms [3],
Chamomile
Improves sleep quality [3] and postmenopausal sexual function [3], but barely effective in anxiety [4].
Lavender
[Silexan] First-line for generalized anxiety, Prescription and approved outside US. Well-tolerated, safe in bipolar.