Zolpidem
[Ambien] Potent z-hypnotic.
Generic
Diphenhydramine
Although over the counter, the prescription version (hydroxyzine) is safer with fewer anticholinergic risks.
Buspirone
Treats anxiety (GAD). Augments in depression but only if anxious. Also improves sexual dysf, bruxism, irritability, PMDD, possibly ADHD.
Dextromethorphan
Think of it as low-potency ketamine. Rapid acting as Auvelity in depression, or as monotherapy (3rd line) in bipolar depression. Abuse potential.
Lithium
Best long-term outcomes in bipolar (I or II) and recurrent depression. Prevents suicide. Treats mania, bp-depression and augments antidepressants.
Celecoxib
[Celebrex] NSAID for treatment-resistant unipolar and bipolar depression, works better if inflammation. Well-tolerated short term, but long-term risks.
Modafinils
[Provigil, Nuvigil] Wakefulness-promoting agents FDA approved for fatigue associated with sleep apnea or shift work. Also treats bipolar depression (2), unipolar depression (3), ADHD (3), and cocaine use disorder.
Naltrexone
[Vivitrol] Opioid blocker treats alcohol and opioid use disorders (and, in combination with bupropion, meth). May help gambling addiciton and antipsychotic weight gain. Inj or oral.