Allopurinol
A well tolerated option for mania, but third-line due to few trials.
Elderly-Safe
Buspirone
Treats anxiety (GAD). Augments in depression but only if anxious. Also improves sexual dysf, bruxism, irritability, PMDD, possibly ADHD.
Baclofen
Muscle relaxant can be very effective for alcohol but has small misuse potential. Also for binge eating.
Acamprosate
[Campral] Well tolerated but low efficacy for alcohol use disorder. May make WD symptoms less aversive.
Disulfiram
(Antabuse) Treats alcoholism by raising the chemical responsible for hangovers. Very effective if patient takes it.
Methylphenidate
First-line stimulant (more neuroprotective and safer for mental health than amphetamine). May help apathy in old age but not for depression.
Modafinils
[Provigil, Nuvigil] Wakefulness-promoting agents FDA approved for fatigue associated with sleep apnea or shift work. Also treats bipolar depression (2), unipolar depression (3), ADHD (3), and cocaine use disorder.
Naltrexone
[Vivitrol] Opioid blocker treats alcohol and opioid use disorders (and, in combination with bupropion, meth). May help gambling addiciton and antipsychotic weight gain. Inj or oral.