Zonisamide
[Zonegran] Last-line for binge eating, weight loss, alcohol [3]. Serious rash risk.
Bipolar-Safe
Valproate
[Depakote] Good for bipolar mania/mixed and comorbid anxiety/alcoholism, but poorly tolerated and unsafe in pregnancy.
Pregabalin
[Lyrica] Approved outside US for generalized and social anxiety disorders [1]. Benzo WD, OCD [3], fibromylagia [1].
Gabapentin
[Neurontin] For social anxiety, stabilizing sleep in alcoholics, RLS, akathisia, non-specific anxiety. Better tolerated than pregabalin but less effective.
Topiramate
[Topamax] PTSD [2], alcohol [2], bulimia [1], borderline/aggression [3], weight [2], OCD [3], meth [1], cocaine [2], gambling [2], schizophrenia aug [1] migraines
Minocycline
[Minocin] Antibiotic/anti-inflammatory with possible benefits in bipolar and unipolar depression; also treats lithium-acne.
Cycloserine
Augments exposure therapy and TMS in low dose, may work for TRD in high dose, but have to get from specialty pharmacy.
Amantadine
Similar to ketamine. Treats TD [2] and irritability in TBI [1]. Last-line secret-weapon for bipolar/unipolar depression, OCD, cognition, DMDD, autism, weight-loss, fatigue.