Bipolar-Safe Archives - Page 3 of 13

Paliperidone

Treatments, Psychotic symptoms, Schizophrenia / Nancy Brandon

[Invega] For schizophrenia and schizoaffective disorder (limited efficacy in mania)

Asenapine

Treatments, BP Depression, Bipolar, Mania, Mixed, Psychotic symptoms, Schizophrenia / Nancy Brandon

[Saphris] A good antipsychotic when others aren't tolerated. Treats bipolar mania/mixed [2] and
possibly bp-depression [4].

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Cariprazine

First line schizophrenia, Bipolar, Treatments, BP Depression, Treatment Resistant Depression, First line mania, Mania, Mixed, Psychotic symptoms, Negative symptoms, Schizophrenia / Nancy Brandon

[$ Vraylar] Top for schizophrenia [1] because it improves negative symptoms. Bipolar depression [2] + mania [1], unipolar augmentation [2], but low effect size in depressions.

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Olanzapine-Fluoxetine

BP Depression, Bipolar, Treatments, Treatment Resistant Depression / Nancy Brandon

[Symbyax] Although weight gain is a problem, can be very effective for depression
(unipolar/bipolar) and mania/mixed.

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Ziprasidone

Treatments, Bipolar, Treatment Resistant Depression, Sleep apnea, Mania, Mixed, Psychotic symptoms, Schizophrenia / Nancy Brandon

[Geodon] Among best antipsychotics for low weight/diabetes risk. Treats mania/mixed; possibly
helps depression in unipolar and bipolar.

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Olanzapine

Bipolar, Treatments, Second line schizophrenia, Treatment Resistant Schizophrenia, Mania, Psychotic Depression, Mixed, Psychotic symptoms, Schizophrenia / Nancy Brandon

[Zyprexa] High efficacy in schizophrenia [2], so use before moving to clozapine. Mania [2], augmentation in unipolar [3], PTSD [3].

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Lurasidone

Treatments, BP Depression, Bipolar, Mixed, Psychotic symptoms, BP Cognition, Schizophrenia / Nancy Brandon

[Latuda] BP-depression [1], depression with mixed features. Improves cognition in bipolar. Does not treat mania.

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Lumateperone

BP Depression, Bipolar, Treatments, Treatment Resistant Depression, Psychotic symptoms, Mixed, Schizophrenia / Nancy Brandon

[$ Caplyta] Among best tolerated antipsychotics for BP-depression [1], also unipolar-depression [2].
Unknown if helps mania. Low dopamine-blocking so well-tolerated in schizophrenia.

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Quetiapine

Generalized Anxiety, Treatments, BP Depression, Bipolar, Deepen Sleep, First line mania, Anxiety, Treatment Resistant Depression, OCD, Mania, Mixed, Psychotic symptoms, Anxious Depression, BP Anxiety, Schizophrenia / Nancy Brandon

[Seroquel] Unique antipsychotic – metabolized into an antidepressant so treats unipolar
depression (and GAD) as monotherapy. Top for TRD [1]. Deepens sleep. Tolerability poor, but among the most
effective options for BP-depression [1], BP-anxiety [2], mania, mixed.

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Varenicline

Treatments, Alcohol, Nicotine, Substance Use Disorders / Nancy Brandon

[Chantix] The most effective therapy for nicotine, generally safe in psychiatric disorders

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