Sertraline (Zoloft)

SSRI antidepressant

Dosing

(mg/d): Depression (50-100), PTSD (50-100), Anxiety disorders (100-200), OCD (200-400), binge eating (100-200)

Management

Side effects: apathy, sexual dysfunction, sleep disruption, nausea, restless legs, akathisia. Warning: osteopenia in post-menopausal women. At doses ≥150 mg/d it has drug interactions, raising levels of meds metabolized through CYP 2D6, 3A4, C19, 2B6. Raise by 3-5x if using with carbamazepine

Safest SSRI in heart disease and possibly in pregnancy/breast-feeding.

EMR Text