Buprenorphine-naloxone
[Suboxone] First line for opioid use disorders
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Substance Use Disorders
Ondansetron
[Zofran] First-line for OCD (very effective, well tolerated). May help binge drinking, bulimia.
Baclofen
Muscle relaxant can be very effective for alcohol [2] but has small misuse potential. Also binge eating [3].
Acamprosate
[Campral] Well tolerated but low efficacy for alcohol use disorder. May make WD symptoms less aversive.
Disulfiram
(Antabuse) Treats alcoholism by raising the chemical responsible for hangovers. Very effective if patient takes it.
Modafinils
[Provigil, Nuvigil] Wakefulness-promoting agents FDA approved for fatigue associated with sleep apnea or shift work. Also treats bipolar depression (2), unipolar depression (3), ADHD (3), and cocaine use disorder.
Atomoxetine
Good for ADHD with anxiety, but least effective among FDA options for ADHD. Avoid in bipolar.
Naltrexone
[Vivitrol] Opioid blocker treats alcohol and opioid use disorders (and, in combination with bupropion, meth). May help gambling addiciton and antipsychotic weight gain. Inj or oral.