Dark-Therapy
Very effective for mania, prevents bipolar, deepens sleep. Mild weight loss.
Hypnotic for Elderly
Dawn-Simulator
Improves morning fatigue and depression, particularly in winter. Can pair with lightbox for depression. Ideal for shift workers and night owls.
Doxepin
[Sinequan/Silenor] Treats sleep in low-dose (esp early am awakening), depression in higher
doses (tricyclic).
Melatonin
Hypnotic with particular benefits in elderly and children with developmental disorders [1], and antipsychotic weight loss [1].
l-Theanine
Extract of green tea. Depression [3], sleep [2], schizophrenia (neg/anx) [2], OCD [3], cognition [3].
Saffron
Well-studied in depression [1], sleep, cognition. Small trials in ADHD [3], OCD [3], weight loss [3], sexual dysfunction [3].
Chamomile
Improves sleep quality [3] and postmenopausal sexual function [3], but barely effective in anxiety [4].
Lavender
[Silexan] First-line for generalized anxiety, Prescription and approved outside US. Well-tolerated, safe in bipolar.
Suvorexant
[$ Belsomra] Orexin antagonist, improves next-day cognition, low abuse potential, low fall risk. Ideal for elderly. However, daridorexant and lemborexant more effective.