Clonidine
[Kapvay] Approved for ADHD, but also helps mania, nicotine/opioid, anxiety, irritability, self-harm, autism, negative symptoms schizophrenia, tics
Schizophrenia
Vortioxetine
[$ Trintellix] Improves cognition. First-line for depression (lacks weight gain, sexual, fatigue SEs; lack of WS). Well studied in elderly.
Topiramate
[Topamax] PTSD [2], alcohol [2], bulimia [1], borderline/aggression [3], weight [2], OCD [3], meth [1], cocaine [2], gambling [2], schizophrenia aug [1] migraines
Minocycline
[Minocin] Antibiotic/anti-inflammatory with possible benefits in bipolar and unipolar depression; also treats lithium-acne.
Trazodone
Deepens sleep quality in low doses, but under-utlilized as an antidepressant, where it can be very effective and tolerable if dosed at night.
Lithium
Best long-term outcomes in bipolar (I or II) and recurrent depression. Prevents suicide. Treats mania, bp-depression and augments antidepressants.