Hot flashes

Venlafaxine

Major Depression, Generalized Anxiety, Depression, Treatments, Panic, Anxiety, Social Anxiety, Chronic Pain, PTSD, Migraines, Hot flashes / Nancy Brandon

[Effexor] Not ideal among the SNRIs (hypertension, WD risks, weight gain), but very effective for some and treats hot flashes in low doses.

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Levomilnacipran

Fibromyalgia, Major Depression, Treatments, Depression, Chronic Pain, Hot flashes / Nancy Brandon

[$ Fetzima] Most noradrenergic of the SNRIs, good for fatigue, with side effect profile similar to
bupropion. Isomer of milnacipran (used in fibromylagia).

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Saffron

Major Depression, Female, Hypnotics, Hypnotic for Elderly, Male, Depression, Treatments, Weight Gain, Age-related or non-specific decline, Deepen Sleep, Dementia, Opioid, SSRI-Induced, OCD, Peripartum Depression, Premenstrual Dysphoria, Hot flashes, ADHD, Sexual Dysfunction / Nancy Brandon

Well-studied in depression [1], sleep, cognition. Small trials in ADHD [3], OCD [3], weight loss [3], sexual dysfunction [3].

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Paroxetine

Major Depression, Generalized Anxiety, Depression, Treatments, Panic, Social Anxiety, PTSD, OCD, Hot flashes / Nancy Brandon

[Paxil] Poor choice as SSRI (higher sexual/weight SE, anticholinergic, pregnancy and WD risks).

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Escitalopram

Major Depression, Generalized Anxiety, First line depression, Depression, Treatments, Panic, Social Anxiety, OCD, Borderline, Hot flashes / Nancy Brandon

[Lexapro] First-line SSRI (no drug interactions, good efficacy in depression/anxiety).

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