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Chris Aiken, MD

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Major Depression

Acetyl-l-carnitine

Major Depression, Age-related or non-specific decline, Treatments, Alcohol, Depression, Treatment Resistant Depression / Nancy Brandon

[ALC] Depression, especially recurrent/TRD, history of child-trauma, or with medical illness or elderly [2]. Alcohol (mood/memory/cravings) [2]

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Saffron

Female, Hypnotics, Major Depression, Male, Depression, Treatments, Weight Gain, Age-related or non-specific decline, Hypnotic for Elderly, SSRI-Induced, Deepen Sleep, Dementia, Opioid, OCD, Peripartum Depression, Premenstrual Dysphoria, Hot flashes, ADHD, Sexual Dysfunction / Nancy Brandon

Well-studied in depression [1], sleep, cognition. Small trials in ADHD [3], OCD [3], weight loss [3], sexual dysfunction [3].

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l-Carnosine

Major Depression, Depression, Treatments, Age-related or non-specific decline, OCD, Negative symptoms, ADHD, Cognition, Schizophrenia / Nancy Brandon

For depression [3], ADHD [3], OCD [3], cognition [3], schizophrenia negative symptoms [3],

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Curcumin

Major Depression, Depression, Treatments, Age-related or non-specific decline, Dementia, Long COVID, Inflammatory Depression / Nancy Brandon

[Tumeric] Antioxidant improves depression [3], cognition, but possible liver risks.

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Palmitoylethanolamide

Major Depression, Autism, Bipolar, Depression, Treatments, Chronic Pain, Mania, Mixed, Migraines, Negative symptoms, Long COVID / Nancy Brandon

[PEA] For mania [3], and augments antidepressants in unipolar [3], autism, neg symptom schizophrenia, migraines and chronic pain.

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Lavender

Hypnotics, Major Depression, Generalized Anxiety, Depression, Treatments, Hypnotic for Elderly, Anxiety, Non-specific Anxiety, Anxious Depression / Nancy Brandon

[Silexan] First-line for generalized anxiety, Prescription and approved outside US. Well-tolerated, safe in bipolar.

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Omega 3 (Fish oil)

Lithium SE, Anorexia, Major Depression, Age-related or non-specific decline, Treatments, Weight Gain, Autism, BP Depression, Bipolar, Depression, DMDD, Migraines, Non-specific Anxiety, Peripartum Depression, Borderline, ADHD, Inflammatory Depression, Acne, Psoriasis, Side Effects / Nancy Brandon

[Fish oil] For bipolar/unipolar depression [2], ADHD, [3], borderline pd [2], irritability, autism, [2], prevention of psychosis [1], dyslipidemia.

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Vitamin B-complex

Major Depression, Depression, Treatments, Negative symptoms, Schizophrenia / Nancy Brandon

For depression [3] and negative symptoms of schizophrenia

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Calcium

Treatments, Premenstrual Dysphoria / Nancy Brandon

For PMDD [2]

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Prazosin

Major Depression, Agitation in Dementia, Treatments, Alcohol, Deepen Sleep, PTSD, Nightmares, Anxious Depression / Nancy Brandon

[Minipress] First-line for PTSD, treats nightmares and daytime symptoms.

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