SAMe
For depression, improves liver health, osteoarthritis, but l-methylfolate has a similar mechanism and better evidence.
Depression
L-methylfolate
[Deplin] Medium effect in depression augmentation [1], may help bipolar depression as well.
Creatine
Augments SSRIs in women only [3]. Improves memory, especially in older adults [2]. Long-COVID [3].
l-Theanine
Extract of green tea. Depression [3], sleep [2], schizophrenia (neg/anx) [2], OCD [3], cognition [3].
Acetyl-l-carnitine
[ALC] Depression, especially recurrent/TRD, history of child-trauma, or with medical illness or elderly [2]. Alcohol (mood/memory/cravings) [2]
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Saffron
Well-studied in depression [1], sleep, cognition. Small trials in ADHD [3], OCD [3], weight loss [3], sexual dysfunction [3].
l-Carnosine
For depression [3], ADHD [3], OCD [3], cognition [3], schizophrenia negative symptoms [3],
Palmitoylethanolamide
[PEA] For mania [3], and augments antidepressants in unipolar [3], autism, neg symptom schizophrenia, migraines and chronic pain.
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