Eszopiclone
Eszopiclone (Lunesta) Hypnotic (GABA-A receptor agonist at subtype involved in sleep (alpha-1); metabolite is agonist at anxiolytic subtype (alpha-2,3,5)) Features […]
Major Depression
Buspirone
Treats anxiety (GAD). Augments in depression but only if anxious. Also improves sexual dysf, bruxism, irritability, PMDD, possibly ADHD.
Dextromethorphan
Think of it as low-potency ketamine. Rapid acting as Auvelity in depression, or as monotherapy (3rd line) in bipolar depression. Abuse potential.
Lithium
Best long-term outcomes in bipolar (I or II) and recurrent depression. Prevents suicide. Treats mania, bp-depression and augments antidepressants.
Celecoxib
[Celebrex] NSAID for treatment-resistant unipolar and bipolar depression, works better if inflammation. Well-tolerated short term, but long-term risks.
Modafinils
[Provigil, Nuvigil] Wakefulness-promoting agents FDA approved for fatigue associated with sleep apnea or shift work. Also treats bipolar depression (2), unipolar depression (3), ADHD (3), and cocaine use disorder.
Pramipexole
Dopamine agonist with powerful benefits in unipolar and bipolar depression, also restless leg syndrome.