Bupropion
[Wellbutrin] First-line for depression (lacks weight-gain, sexual, cognitive, fatigue SEs; lack of WD). Safest antidepressant in bipolar. Treats nicotine but not as well as varenicline. Treats ADHD a little; RLS.
Major Depression
Lamotrigine
[Lamictal] Best tolerated mood stabilizer, treats and prevents bp-depression; does not treat mania so avoid as monotherapy in bipolar I.
Minocycline
[Minocin] Antibiotic/anti-inflammatory with possible benefits in bipolar and unipolar depression; also treats lithium-acne.
Cycloserine
Augments exposure therapy and TMS in low dose, may work for TRD in high dose, but have to get from specialty pharmacy.
Amantadine
Similar to ketamine. Treats TD [2] and irritability in TBI [1]. Last-line secret-weapon for bipolar/unipolar depression, OCD, cognition, DMDD, autism, weight-loss
Sertraline
[Zoloft] Good choice overall, best SSRI for heart disease, no CYP drug interactions below 150mg.
Paroxetine
[Paxil] Poor choice as SSRI (higher sexual/weight SE, anticholinergic, pregnancy and WD risks).