Clonidine
[Kapvay] Approved for ADHD, but also helps mania, nicotine/opioid, anxiety, irritability, self-harm, autism, negative symptoms schizophrenia, tics
Bipolar
Nimodipine
[CA CHANNEL BLOCKER] for mania [3], rapid cycling bipolar, and tremor, (may help bp-anxiety).
Lamotrigine
[Lamictal] Best tolerated mood stabilizer, treats and prevents bp-depression; does not treat mania so avoid as monotherapy in bipolar I.
Carbamazepine
[Equetro] A well tolerated option for bipolar mania and mixed states (but you’ll need to adjust for drug interactions)
Valproate
[Depakote] Good for bipolar mania/mixed and comorbid anxiety/alcoholism, but poorly tolerated and unsafe in pregnancy.
Pregabalin
[Lyrica] Approved outside US for generalized and social anxiety disorders [1]. Benzo WD, OCD [3], fibromylagia [1].
Gabapentin
[Neurontin] For social anxiety, stabilizing sleep in alcoholics, RLS, akathisia, non-specific anxiety. Better tolerated than pregabalin but less effective.
Amantadine
Similar to ketamine. Treats TD [2] and irritability in TBI [1]. Last-line secret-weapon for bipolar/unipolar depression, OCD, cognition, DMDD, autism, weight-loss, fatigue.