Lurasidone
[Latuda] BP-depression [1], depression with mixed features. Improves cognition in bipolar. Does not treat mania.
Mixed
Lumateperone
[$ Caplyta] Among best tolerated antipsychotics for BP-depression [1], also unipolar-depression [2].
Unknown if helps mania. Low dopamine-blocking so well-tolerated in schizophrenia.
Quetiapine
[Seroquel] Unique antipsychotic – metabolized into an antidepressant so treats unipolar
depression (and GAD) as monotherapy. Top for TRD [1]. Deepens sleep. Tolerability poor, but among the most
effective options for BP-depression [1], BP-anxiety [2], mania, mixed.
Palmitoylethanolamide
[PEA] For mania [3], and augments antidepressants in unipolar [3], autism, neg symptom schizophrenia, migraines and chronic pain.
Palmitoylethanolamide Read More »
Clonidine
[Kapvay] Approved for ADHD, but also helps mania, nicotine/opioid, anxiety, irritability, self-harm, autism, negative symptoms schizophrenia, tics
Nimodipine
[CA CHANNEL BLOCKER] for mania [3], rapid cycling bipolar, and tremor, (may help bp-anxiety).
Carbamazepine
[Equetro] A well tolerated option for bipolar mania and mixed states (but you’ll need to adjust for drug interactions)
Valproate
[Depakote] Good for bipolar mania/mixed and comorbid anxiety/alcoholism, but poorly tolerated and unsafe in pregnancy.