Lumateperone
[$ Caplyta] Among best tolerated antipsychotics for BP-depression [1], also unipolar-depression [2].
Unknown if helps mania. Low dopamine-blocking so well-tolerated in schizophrenia.
Quetiapine
[Seroquel] Unique antipsychotic – metabolized into an antidepressant so treats unipolar
depression (and GAD) as monotherapy. Top for TRD [1]. Deepens sleep. Tolerability poor, but among the most
effective options for BP-depression [1], BP-anxiety [2], mania, mixed.
Solriamfetol
[$ Sunosi] Approved for narcolepsy but has bupropion-like properties and may treat ADHD.
Varenicline
[Chantix] The most effective therapy for nicotine, generally safe in psychiatric disorders
Thyroid T4
[Synthroid] Use for hypothyroidism on lithium. For augmentation in depression, T3 is preferred.
Thyroid T3
[Cytomel] For treatment-resistant bipolar/unipolar depression, well-tolerated and may actually improve manic or anxious symptoms
Tranylcypromine
[Parnate] Ideal MAOI for tolerability, with low weight/sedation problems. May treat panic.