Fluvoxamine (Luvox)

SSRI antidepressant

Dosing

(mg/d): Depression (50-100), Anxiety disorders (100-150), OCD (200-300).

Management

Side effects: apathy, sexual dysfunction, sleep disruption, nausea, restless legs, akathisia. Warning: osteopenia in post-menopausal women. Raises levels of meds metabolized through CYP 2D6, 3A4, 2B6. Raise dose by x1.3 if using with carbamazepine. Raises meds metabolized by CYP1A2 (strong), CYP2C19 (strong), CYP2B6 (weak), CYP2C9 (weak), CYP2D6 (weak), CYP3A4 (weak).

Only FDA approved in OCD. 2nd worst SSRI WD risks (after paroxetine).

EMR Text