Viloxazine ($ Qelbree)
Antidepressant structure (norepinephrine reuptake inhibitor)
- ADHD
- Approved for depression outside the US
- Depression in Alcohol use disorder
Avoid in bipolar
Features
Dosing
Start 100-200mg daily, raise every week. Max 400 mg/d (peds) 600 mg/d (adults). Start higher if over age 12.
Management
Sedation, hypertension. Strong CYP1A2 inhibitor.
A noradrenergic antidepressant used from 1970-2000 in Europe, but fell off the market due to poor sales, then reborn as ADHD treatment in XR form. About half as effective as stimulants and similar efficacy to atomoxetine. Benefits build up over 4 weeks.
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