Topiramate (Topamax)
Anticonvulsant (GABA, glutamate facilitation of GABA transmission, receptor antagonist on AMPA and KA)
- PTSD
- Bulimia
- SE-weight loss
- Methamphetamine
- Schizophrenia Negative Symptoms
- Migraines
- Alcohol
- Irriability
- OCD
- Cocaine
- Clozapine resistant schizophrenia
Features
Dosing
50-200mg/d, raise slowly (by 25mg/wk) to prevent cognitive side effects. Up to 600mg/d in binge eating.
Management
SE: Dizzy, imbalance, cognitive impairment. Warning: renal stones
Can treat psychosis in schizophrenia (particularly when resistant to clozapine), but paradoxically can also cause psychosis.
Protects against damage from meth/amphetamine/cocaine abuse.
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