Sedating Archives - Page 6 of 7

Lemborexant

[$ Dayvigo] Orexin antagonist, improves next-day cognition, low abuse potential, low fall risk. Ideal for elderly.

[$ Quviviq] Orexin antagonist, improves next-day cognition, low abuse potential, low fall risk. Ideal for elderly.

[Rozerem] Safe hypnotic that may improve depression in bipolar disorder. Think of it as a potent melatonin.

Natural hypnotic and anxiolytic, safe in elderly.

[Lunesta]Among the z-hypnotics, has the most benzo-like properties, and can augment antidepressants (short term) in depression and GAD.

[Ambien] Potent z-hypnotic.

[Sonata] Z-hypnotic with the lowest risk of morning sedation.

Although over the counter, the prescription version (hydroxyzine) is safer with fewer anticholinergic risks.

Think of it as low-potency ketamine. Rapid acting as Auvelity in depression, or as monotherapy (3rd line) in bipolar depression. Abuse potential.

Muscle relaxant can be very effective for alcohol [2] but has small misuse potential. Also binge eating [3].