Sedating Archives - Page 3 of 7

Olanzapine

Bipolar, Treatments, Second line schizophrenia, Treatment Resistant Schizophrenia, Mania, Psychotic Depression, Mixed, Psychotic symptoms, Schizophrenia / Nancy Brandon

[Zyprexa] High efficacy in schizophrenia [2], so use before moving to clozapine. Mania [2], augmentation in unipolar [3], PTSD [3].

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Lurasidone

Treatments, BP Depression, Bipolar, Mixed, Psychotic symptoms, BP Cognition, Schizophrenia / Nancy Brandon

[Latuda] BP-depression [1], depression with mixed features. Improves cognition in bipolar. Does not treat mania.

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Lumateperone

BP Depression, Bipolar, Treatments, Treatment Resistant Depression, Psychotic symptoms, Mixed, Schizophrenia / Nancy Brandon

[$ Caplyta] Among best tolerated antipsychotics for BP-depression [1], also unipolar-depression [2].
Unknown if helps mania. Low dopamine-blocking so well-tolerated in schizophrenia.

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Quetiapine

Generalized Anxiety, Treatments, BP Depression, Bipolar, Deepen Sleep, First line mania, Anxiety, Treatment Resistant Depression, OCD, Mania, Mixed, Psychotic symptoms, Anxious Depression, BP Anxiety, Schizophrenia / Nancy Brandon

[Seroquel] Unique antipsychotic – metabolized into an antidepressant so treats unipolar
depression (and GAD) as monotherapy. Top for TRD [1]. Deepens sleep. Tolerability poor, but among the most
effective options for BP-depression [1], BP-anxiety [2], mania, mixed.

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Phenelzine

Major Depression, Depression, Treatments, Anxiety, Social Anxiety, Treatment Resistant Depression, Anxious Depression / Nancy Brandon

[Nardil] Ideal MAOI for anxiety, and more effective for social anxiety than SSRIs.

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Iscarboxazid

Major Depression, Depression, Treatments, Anxiety, Social Anxiety / Nancy Brandon

[Marplan] Third-line among the MAOIs (least studied of the bunch).

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Ropinorole

Bipolar, Treatments, BP Depression, Restless leg syndrome / Nancy Brandon

[Requip] Similar to pramipexole but not as clearly effective in depression

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Esketamine

Major Depression, Treatments, BP Depression, Treatment Resistant Depression / Nancy Brandon

[$ Spravato] Strong, rapid medication for TRD [2], but works no better than placebo after a month and risky (used to model schizophrenia and autism). Ketamine IV is more effective but isn’t covered by insurance

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Melatonin

Hypnotics in Sleep Apnea, Hypnotics, Weight Gain, Treatments, Hypnotic for Elderly, Deepen Sleep, Dementia, Migraines, Sleep, Side Effects / Chris

Hypnotic with particular benefits in elderly and children with developmental disorders [1], and antipsychotic weight loss [1].

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l-Theanine

Hypnotics, Major Depression, Hypnotic for Elderly, Depression, Age-related or non-specific decline, Treatments, Deepen Sleep, Anxiety, OCD, Augmentation, Non-specific Anxiety, Anxious Depression, Negative symptoms, Cognition, Schizophrenia / Nancy Brandon

Extract of green tea. Depression [3], sleep [2], schizophrenia (neg/anx) [2], OCD [3], cognition [3].

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