Pimavanserin
[$ Nuplazid] Use for psychosis in Parkinson's disease, has had inconsistent results in other
disorders.
Sedating
Brexpiprazole
[$ Rexulti] Well tolerated for antipsychotics, treats unipolar-depression, ptsd, but not bp-
depression and not mania.
Aripiprazole
[Abilify] Among the better-tolerated antipsychotics, and best-studied for antidepressant
augmentation [1] (but doesn't treat bp-depression). Schizophrenia [1]
Clozapine
[Clozaril] Use in schizophrenia/schizoaffective after 2 failed antipsychotic trials. Prevents suicide
in psychotic disorders.
Risperidone
[Risperdal] Among most effective antipsychotics for schizophrenia [1]. Mania[3]. Augments
antidepressants in unipolar [3], PTSD [3], OCD [3].
Asenapine
[Saphris] A good antipsychotic when others aren't tolerated. Treats bipolar mania/mixed [2] and
possibly bp-depression [4].
Cariprazine
[$ Vraylar] Top for schizophrenia [1] because it improves negative symptoms. Bipolar depression [2] + mania [1], unipolar augmentation [2], but low effect size in depressions.
Olanzapine-Fluoxetine
[Symbyax] Although weight gain is a problem, can be very effective for depression
(unipolar/bipolar) and mania/mixed.
Olanzapine-Fluoxetine Read More »
Ziprasidone
[Geodon] Among best antipsychotics for low weight/diabetes risk. Treats mania/mixed; possibly
helps depression in unipolar and bipolar.