Granisetron
[$ Sancuso] A second-line alternative to ondansetron.
Non-sedating
Gepirone
[$ Exxua] Similar to buspirone but not as useful (costly, requires EKG testing, failed in most depression trials)
Buspirone
Treats anxiety (GAD). Augments in depression but only if anxious. Also improves sexual dysf, bruxism, irritability, PMDD
Lithium
Best long-term outcomes in bipolar (I or II) and recurrent depression. Prevents suicide. Treats mania, bp-depression and augments antidepressants.
Celecoxib
[Celebrex] NSAID for treatment-resistant unipolar and bipolar depression [3], works better if inflammation [2]. Well-tolerated short term, but long-term risks.
Acamprosate
[Campral] Well tolerated but low efficacy for alcohol use disorder. May make WD symptoms less aversive.
Methylphenidate
First-line stimulant (more neuroprotective and safer for mental health than amphetamine). May help apathy in old age but not for depression.