Zaleplon
[Sonata] Z-hypnotic with the lowest risk of morning sedation.
Medication
Lithium
Best long-term outcomes in bipolar (I or II) and recurrent depression. Prevents suicide. Treats mania, bp-depression and augments antidepressants.
Baclofen
Muscle relaxant can be very effective for alcohol but has small misuse potential. Also for binge eating.
Acamprosate
[Campral] Well tolerated but low efficacy for alcohol use disorder. May make WD symptoms less aversive.
Methylphenidate
First-line stimulant (more neuroprotective and safer for mental health than amphetamine). May help apathy in old age but not for depression.
Modafinils
[Provigil, Nuvigil] Wakefulness-promoting agents FDA approved for fatigue associated with sleep apnea or shift work. Also treats bipolar depression (2), unipolar depression (3), ADHD (3), and cocaine use disorder.
Pramipexole
Dopamine agonist with powerful benefits in unipolar and bipolar depression, also restless leg syndrome.