Suvorexant
Suvorexant ($ Belsomra) Hypnotic (Orexin antagonist) Features Dosing 10mg 1 qhs prn insomnia (do not take within 30min of eating) […]
Generic
Daridorexant
Daridorexant(Quivig $) Hypnotic (Orexin antagonist) hypnotic deepen sleep Features Dosing 25-50mg qhs prn insomnia (do not take within 30min of
Ramelteon
Ramelteon(Rozerem) Hypnotic (melatonin agonist) Features Dosing 8mg/night. Can take PRN, but may work better when taken at the same time
Valerian
Valerian CAM (GABA agonist; serotonin 5-HT5A agonist) Features Dosing 450-600mg 2 hr before bedtime Management Liver risks. EMR Text
Eszopiclone
Eszopiclone (Lunesta) Hypnotic (GABA-A receptor agonist at subtype involved in sleep (alpha-1); metabolite is agonist at anxiolytic subtype (alpha-2,3,5)) Features
Zolpidem
Zolpidem (Ambien) Hypnotic (GABA-A receptor agonist at subtype involved in sleep (alpha-1)) Features Dosing 5-10 mg/night (6.25-12.5 for CR). Use
Diphenhydramine
Although over the counter, the prescription version (hydroxyzine) is safer with fewer anticholinergic risks.
Buspirone
Treats anxiety (GAD). Augments in depression but only if anxious. Also improves sexual dysf, bruxism, irritability, PMDD, possibly ADHD.