Child-Approved Archives - Chris Aiken, MD

Folinic Acid

[Leucovorin] FDA-approved for autism, addresses a known mechanism there.

One of the most effective therapies for TRD. Well tolerated, improves cognition and neuroplasticity.

[Anafranil] Highly serotonergic, very effective for OCD (tricyclic).

[Sumontil] Third-line tricyclic, mix of serotonin/noripineprhine, more anticholinergic side
effects.

[Vivactil] First-line tricyclic, low sedation/anticholinergic/hypotension risk. More noradrenergic.

[Norpramin] Second-line tricyclic, low sedation/anticholinergic/hypotension risk. More
noradrenergic.

[Sinequan/Silenor] Treats sleep in low-dose (esp early am awakening), depression in higher
doses (tricyclic).

[Elavil] Third-line tricyclic, mix of serotonin/noripineprhine, more anticholinergic side effects.
Useful for pain and IBS.

[Cymbalta] Approved for child anxiety. Risk of urine retention (but treats urine incont). Liver
risk.

[$ Rexulti] Well tolerated for antipsychotics, treats unipolar-depression, ptsd, but not bp-
depression and not mania.