Nefazodone (Serzone)
Antidepressant (serotonin receptor antagonist (5-HT2), receptor agonist (5-HT1A))
- Major Depression
- Similar to trazodone but less sedating
Features
Dosing
300-600 mg/night.
Management
Well-tolerated except fatigue. Lacks sexual side effects. Main draw-back is a rare risk of hepatotoxicity (1:20,000 – 1:100,000). Antagonist at serotonin 5-HT2A receptors (like trazodone, seroquel, zyprexa, mirtazapine – this causes sedation).
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