Naproxyn(Naprosyn)

NSAID (COX-1 and COX-2 inhibitor, antiinflammatory)

Dosing

250mg/d as augmentation to SSRI in OCD

Management

Main risks are long-term (renal, gastritis/ulcer, cardiac) so best to give for 6 months to get them better and then try to stop. Caution with lithium interactions. Recommend to take with a proton-pump inhibitor to prevent ulceration/GI bleed (Pantoprazole is go-to, but also omeprazole, lansoprazole, dexlansoprazole, esomeprazole, rabeprazole).

Supported by one RCT in OCD and theoretical basis of inflammation in OCD.

EMR Text