Folinic acid (Leucovorin, Wellcovorin)

CAM (folate precursor)

  • Autism1

Features

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Handout

Dosing

Folinic acid 2 mg/kg/day, max 50 mg/day, divided bid

Management

Addresses folate deficiency in autism caused by folate autoantibody receptors (that prevent transport into the brain and are present in 30-80%).

EMR Text

Autism

Folinic acid (Leucovorin, Wellcovorin) used based on small randomized trials in autism spectrum disorder and FDA approval there.

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