Enlyte - Chris Aiken, MD

Enlyte (Methylfolate Multivitamin)

CAM (includes methylfolate – involved in production of serotonin, norephinephrine, dopamine)

Major Depression²
Peripartum Depression²

Cognition
Bipolar Depression³

Features

Non-sedating, Elderly-Safe, Child-Approved, Tolerable, Non-controlled, Natural, Weight-Free, Bipolar-Safe, Sexual-free, Elderly-Preferred

Handout

Dosing

1 cap/day

Management

Contains several vitamins with evidence in depression (l-methylfolate, B-complex, iron, omega-3, magnesium, zinc, coenzyme Q10), so can stop other vitamins if they are in Enlyte. Can try for 2 months with $30/month coupon (www.enlyterx.com) to see if works. Large effect size in depression as monotherapy in patients with MTHFR gene abnormalities. Also available as EnBrace HR, which is identical but marketed for peripartum.

EMR Text

Depression

Enlyte use based on FDA clearance in depression and efficacy in a large controlled trial (Mech AW and Farah A, J Clin Psychiatry 2016;77(5):668-71).

Enlyte side effects reviewed with patient

Bipolar Depression

Enlyte use based on FDA clearance in depression and efficacy of its individual ingredients in controlled trials of bipolar depression (eg, methylfolate, omega-3, coq10).

Enlyte side effects reviewed with patient

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