Lemon Balm
Improves sleep quality [2] and mild depression, anxiety, stress symptoms [2-3]
Improves morning fatigue and depression, particularly in winter. Can pair with lightbox for depression. Ideal for shift workers and night owls.
Very effective and well tolerated for depression regardless of season (also for bipolar, PTSD, bulimia, shift work)
Improves sleep (with melatonin), bruxism, and essential for liver health in alcohol use disorder.
[Pamelor] First-line tricyclic, low sedation/anticholinergic/hypotension risk. More
noradrenergic.
[Sinequan/Silenor] Treats sleep in low-dose (esp early am awakening), depression in higher
doses (tricyclic).
[Elavil] Third-line tricyclic, mix of serotonin/noripineprhine, more anticholinergic side effects.
Useful for pain and IBS.
[Seroquel] Unique antipsychotic – metabolized into an antidepressant so treats unipolar
depression (and GAD) as monotherapy. Top for TRD [1]. Deepens sleep. Tolerability poor, but among the most
effective options for BP-depression [1], BP-anxiety [2], mania, mixed.
For bipolar/unipolar depression [2], ADHD [3], anxiety [2], cognition [2], autism [2], weight loss [1], dyslipidemia, long COVID [1].