First line schizophrenia

Aripiprazole

First line schizophrenia, Major Depression, Bipolar, Treatments, Autism, Treatment Resistant Depression, OCD, Tics, Augmentation, Mania, Psychotic Depression, Mixed, Psychotic symptoms, Prolactinemia, Schizophrenia / Nancy Brandon

[Abilify] Among the better-tolerated antipsychotics, and best-studied for antidepressant
augmentation [1] (but doesn't treat bp-depression). Schizophrenia [1]

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Cariprazine

First line schizophrenia, BP Depression, Bipolar, Treatments, First line mania, Treatment Resistant Depression, Mania, Mixed, Psychotic symptoms, Negative symptoms, Schizophrenia / Nancy Brandon

[$ Vraylar] Top for schizophrenia [1] because it improves negative symptoms. Bipolar depression [2] + mania [1], unipolar augmentation [2], but low effect size in depressions.

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Xanomeline-trospium

First line schizophrenia, Treatments, Psychotic symptoms, Schizophrenia / Nancy Brandon

[$ Cobenfy] First-line antipsychotic for schizophrenia (lacks long-term risks, though GI issues a problem at start). Not effective in other disorders.

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