Treatment Resistant Depression Archives - Page 2 of 4

Cariprazine

First line schizophrenia, BP Depression, Bipolar, Treatments, Treatment Resistant Depression, First line mania, Mania, Mixed, Psychotic symptoms, Negative symptoms, Schizophrenia / Nancy Brandon

[$ Vraylar] Top for schizophrenia [1] because it improves negative symptoms. Bipolar depression [2] + mania [1], unipolar augmentation [2], but low effect size in depressions.

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Olanzapine-Fluoxetine

BP Depression, Bipolar, Treatments, Treatment Resistant Depression / Nancy Brandon

[Symbyax] Although weight gain is a problem, can be very effective for depression
(unipolar/bipolar) and mania/mixed.

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Ziprasidone

Treatments, Bipolar, Treatment Resistant Depression, Sleep apnea, Mania, Mixed, Psychotic symptoms, Schizophrenia / Nancy Brandon

[Geodon] Among best antipsychotics for low weight/diabetes risk. Treats mania/mixed; possibly
helps depression in unipolar and bipolar.

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Lumateperone

BP Depression, Bipolar, Treatments, Treatment Resistant Depression, Mixed, Psychotic symptoms, Schizophrenia / Nancy Brandon

[$ Caplyta] Among best tolerated antipsychotics for BP-depression [1], also unipolar-depression [2].
Unknown if helps mania. Low dopamine-blocking so well-tolerated in schizophrenia.

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Quetiapine

Generalized Anxiety, Treatments, BP Depression, Bipolar, Deepen Sleep, First line mania, Anxiety, Treatment Resistant Depression, OCD, Mania, Mixed, Psychotic symptoms, Anxious Depression, BP Anxiety, Schizophrenia / Nancy Brandon

[Seroquel] Unique antipsychotic – metabolized into an antidepressant so treats unipolar
depression (and GAD) as monotherapy. Top for TRD [1]. Deepens sleep. Tolerability poor, but among the most
effective options for BP-depression [1], BP-anxiety [2], mania, mixed.

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Thyroid T3

Bipolar, Treatments, BP Depression, Treatment Resistant Depression / Nancy Brandon

[Cytomel] For treatment-resistant bipolar/unipolar depression, well-tolerated and may actually improve manic or anxious symptoms

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Tranylcypromine

Major Depression, Treatments, Panic, Depression, Anxiety, Social Anxiety, Treatment Resistant Depression / Nancy Brandon

[Parnate] Ideal MAOI for tolerability, with low weight/sedation problems. May treat panic.

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Phenelzine

Major Depression, Depression, Treatments, Anxiety, Social Anxiety, Treatment Resistant Depression, Anxious Depression / Nancy Brandon

[Nardil] Ideal MAOI for anxiety, and more effective for social anxiety than SSRIs.

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Esketamine

Major Depression, BP Depression, Treatments, Treatment Resistant Depression / Nancy Brandon

[$ Spravato] Strong, rapid medication for TRD [2], but works no better than placebo after a month and risky (used to model schizophrenia and autism). Ketamine IV is more effective but isn’t covered by insurance

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Probiotics

Major Depression, Generalized Anxiety, Female, BP Depression, Age-related or non-specific decline, Treatments, Autism, Bipolar, Depression, Anxiety, Deepen Sleep, Treatment Resistant Depression, Anxious Depression, Negative symptoms, Peripartum Depression, Borderline, Sleep, ADHD, Long COVID, Inflammatory Depression, Cognition, Schizophrenia, Sexual Dysfunction / Nancy Brandon

For bipolar/unipolar depression [2], ADHD [3], anxiety [2], cognition [2], autism [2], weight loss [1], dyslipidemia, long COVID [1].

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