Treatment Resistant Depression

Dextromethorphan

BP Depression, Treatments, Treatment Resistant Depression, Bipolar / Nancy Brandon

Think of it as low-potency ketamine. Rapid acting as Auvelity in depression, or as monotherapy (3rd line) in bipolar depression. Abuse potential.

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Lithium

BP Depression, Major Depression, Treatments, Treatment Resistant Depression, Negative symptoms, Bipolar, Mania, Mixed, Psychotic Depression, Schizophrenia / Nancy Brandon

Best long-term outcomes in bipolar (I or II) and recurrent depression. Prevents suicide. Treats mania, bp-depression and augments antidepressants.

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Celecoxib

BP Depression, Major Depression, Treatment Resistant Depression, Bipolar, Treatments, Peripartum Depression / Nancy Brandon

[Celebrex] NSAID for treatment-resistant unipolar and bipolar depression, works better if inflammation. Well-tolerated short term, but long-term risks.

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Pramipexole

BP Depression, Major Depression, Treatment Resistant Depression, Bipolar / Chris

Dopamine agonist with powerful benefits in unipolar and bipolar depression, also restless leg syndrome.

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