Treatment Resistant Depression Archives

Lightbox

Fibromyalgia, First line depression, BP Depression, Male, Treatments, Depression, Bulimia, Treatment Resistant Depression, Deepen Sleep, PTSD, Negative symptoms, Peripartum Depression, Vascular Depression / Chris

Very effective and well tolerated for depression regardless of season (also for bipolar, PTSD, bulimia, shift work)

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ECT

BP Depression, Treatments, Treatment Resistant Depression, Psychotic Depression / Chris

First-line for severe psychotic depression. In other cases of TRD, may prefer over TMS if severe. Also works for bipolar depression.

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TMS

BP Depression, Treatments, Treatment Resistant Depression, Nicotine, OCD, Vascular Depression, Inflammatory Depression / Chris

One of the most effective therapies for TRD. Well tolerated, improves cognition and neuroplasticity.

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Imipramine

Major Depression, Generalized Anxiety, Depression, Treatments, Panic, Anxiety, Treatment Resistant Depression, Binge Eating, Anxious Depression, Eating Disorders / Nancy Brandon

[Tofranil] Ideal tricyclic for anxiety disorders, but sedating and anticholinergic effects.

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Protriptyline

Major Depression, Treatments, Treatment Resistant Depression / Nancy Brandon

[Vivactil] First-line tricyclic, low sedation/anticholinergic/hypotension risk. More noradrenergic.

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Nortriptyline

Major Depression, Depression, Treatments, Treatment Resistant Depression, Deepen Sleep, Psychotic Depression, Migraines, Inflammatory Depression / Nancy Brandon

[Pamelor] First-line tricyclic, low sedation/anticholinergic/hypotension risk. More
noradrenergic.

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Desipramine

Major Depression, Treatments, Treatment Resistant Depression, ADHD / Nancy Brandon

[Norpramin] Second-line tricyclic, low sedation/anticholinergic/hypotension risk. More
noradrenergic.

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Brexpiprazole

Agitation in Dementia, Treatments, Treatment Resistant Depression, PTSD, Psychotic symptoms, Schizophrenia / Nancy Brandon

[$ Rexulti] Well tolerated for antipsychotics, treats unipolar-depression, ptsd, but not bp-
depression and not mania.

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Aripiprazole

First line schizophrenia, Major Depression, Bipolar, Treatments, Autism, Treatment Resistant Depression, Tics, Augmentation, Mania, Psychotic Depression, OCD, Psychotic symptoms, Mixed, Prolactinemia, Schizophrenia / Nancy Brandon

[Abilify] Among the better-tolerated antipsychotics, and best-studied for antidepressant
augmentation [1] (but doesn't treat bp-depression). Schizophrenia [1]

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Risperidone

Autism, Bipolar, Treatments, Treatment Resistant Depression, Mania, PTSD, Mixed, Psychotic symptoms, Schizophrenia / Nancy Brandon

[Risperdal] Among most effective antipsychotics for schizophrenia [1]. Mania[3]. Augments
antidepressants in unipolar [3], PTSD [3], OCD [3].

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