Major Depression

Eszopiclone

Generalized Anxiety, Hypnotics, Treatments, Anxiety, Anxious Depression, Sleep / Nancy Brandon

[Lunesta]Among the z-hypnotics, has the most benzo-like properties, and can augment antidepressants (short term) in depression and GAD.

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Buspirone

Generalized Anxiety, Treatments, SSRI-Induced, Anxious Depression, Bruxism, Premenstrual Dysphoria, Sexual Dysfunction / Nancy Brandon

Treats anxiety (GAD). Augments in depression but only if anxious. Also improves sexual dysf, bruxism, irritability, PMDD

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Dextromethorphan

Agitation in Dementia, Treatments, BP Depression, Bipolar, Treatment Resistant Depression / Nancy Brandon

Think of it as low-potency ketamine. Rapid acting as Auvelity in depression, or as monotherapy (3rd line) in bipolar depression. Abuse potential.

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Lithium

Major Depression, First line BP depression, Bipolar, Treatments, BP Depression, Treatment Resistant Depression, First line mania, Mania, Psychotic Depression, Mixed, Negative symptoms, Schizophrenia / Nancy Brandon

Best long-term outcomes in bipolar (I or II) and recurrent depression. Prevents suicide. Treats mania, bp-depression and augments antidepressants.

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Celecoxib

Major Depression, Treatments, BP Depression, Bipolar, Treatment Resistant Depression, Peripartum Depression, Inflammatory Depression / Nancy Brandon

[Celebrex] NSAID for treatment-resistant unipolar and bipolar depression [3], works better if inflammation [2]. Well-tolerated short term, but long-term risks.

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Modafinils

Major Depression, Treatments, BP Depression, Sleep apnea, Methamphetamine, BP Cognition, Cocaine, ADHD, Cognition / Nancy Brandon

[Provigil, Nuvigil] Wakefulness-promoting agents FDA approved for fatigue associated with sleep apnea or shift work. Also treats bipolar depression (2), unipolar depression (3), ADHD (3), and cocaine use disorder.

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